Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

This is an Accepted Manuscript of an article published by Taylor & Francis in Chronobiology International on 28 June 2018, available online: http://www.tandfonline.com/10.1080/07420528.2018.1475395.Rhythms can be observed at all levels of the biologic integration in humans. The observation that a biological or physiological variable shows a circadian rhythm can be explained by several multifactorial systems including external (exogenous), internal (endogenous) and psychobiological (lifestyle) mechanisms. Our body clock can be synchronized with the environment by external factors, called “synchronizers”, i.e. the light–dark cycle, but it is also negatively influenced by some pathological conditions or factors, called “chronodisruptors,” i.e. aging or low physical activity (PA). The desynchronization of a 24-h rhythm in a chronic manner has been recently defined “chronodisruption” or “circadian disruption.” A very large number of hormonal variables, such as adrenal and gonadal stress steroids, are governed by circadian rhythmicity. Such hormones, in normal conditions, show a peak in the first part of the day, while their typical diurnal fluctuations are totally out of sync in subjects affected by cancer or metabolic diseases, such as obesity, diabetes and metabolic syndrome. In general, a flatter slope with altered peaks in cortisol and testosterone circadian rhythms has been observed in pathological individuals. PA, specifically chronic exercise, seems to play a key role as synchronizer for the whole circadian system in such pathologies even if specific data on steroids circadian pattern are still sparse and contradictory. Recently, it has been proposed that low-intensity chronic PA could be an effective intervention to decrease morning cortisol levels in pathological subjects. The standardization of all confounding factors is needed to reach more clear evidence-based results

Multiple-Hypothesis Path Planning with Uncertain Object Detections

Path planning in obstacle-dense environments is a key challenge in robotics, and depends on inferring scene attributes and associated uncertainties. We present a multiple-hypothesis path planner designed to navigate complex environments using obstacle detections. Path hypotheses are generated by reasoning about uncertainty and range, as initial detections are typically at far ranges with high uncertainty, before subsequent detections reduce this uncertainty. Given estimated obstacles, we build a graph of pairwise connections between objects based on the probability that the robot can safely pass between the pair. The graph is updated in real time and pruned of unsafe paths, providing probabilistic safety guarantees. The planner generates path hypotheses over this graph, then trades between safety and path length to intelligently optimize the best route. We evaluate our planner on randomly generated simulated forests, and find that in the most challenging environments, it increases the navigation success rate over an A* baseline from 20% to 75%. Results indicate that the use of evolving, range-based uncertainty and multiple hypotheses are critical for navigating dense environments

Effect of a Habitual Late-Evening Physical Task on Sleep Quality in Neither-Type Soccer Players

Purpose: The aim of this study was to investigate objective and subjective sleep quality, daytime tiredness and sleepiness in response to a late-evening high intensity interval training (HIIT) session in neither-type soccer players that habitually trained late in the day. This is the first study that considered both athletes’ chronotype and habitual training time as crucial factors when assessing sleep quality in relation to an evening physical task.Methods: In this longitudinal, prospective, observational study, 14 Italian soccer players were recruited (mean age: 26.1 ± 4.5 years; height: 1.81 ± 0.06 m; weight: 78.9 ± 6.1 kg) and performed an extra-routine 4 × 4-min HIIT session at 09:00 p.m. Players used to train always between 09:00 and 11:00 p.m during the competitive season. All subjects wore an actigraph to evaluate their objective sleep parameters and a sleep diary was used to record subjective values of sleep quality, daytime tiredness, and daytime sleepiness. All data were analyzed as: the mean of the two nights before (PRE), the night after (POST 1), and the mean of the two nights after (POST 2) the extra-routine HIIT session. The subjects’ chronotype was assessed by the morningness-eveningness questionnaire (MEQ).Results: All players were classified as N-types (mean MEQ score: 49.4 ± 3.7). None of the actigraph parameters nor the subjective values of sleep quality, tiredness, and sleepiness showed significant changes in PRE, POST 1, and POST 2.Conclusion: The results of our study added more information regarding sleep quality outcomes in response to a late-evening HIIT session. Athletic trainers and medical staff should always control for chronotype and habitual training time when assessing variations to sleep quality in athletes

Notulae to the Italian alien vascular flora: 11

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1

Contributi per una flora vascolare di Toscana. XII (739-812)

Vengono presentate nuove località e/o conferme relative a 74 taxa specifici e sottospecifici di piante vascolari della flora vascolare to- scana, appartenenti a 69 generi e 28 famiglie: Bunium, Trinia (Apia- ceae), Nerium (Apocynaceae), Lemna (Araceae), Artemisia, Bidens, Centaurea, Crupina, Gazania, Hieracium, Rhagadiolus, Symphyotri- chum, Tagetes, Tripleurospermum (Asteraceae), Impatiens (Balsami- naceae), Anredera (Basellaceae), Cynoglottis, Phacelia (Boraginaceae), Cardamine, Diplotaxis, Hornungia (Brassicaceae), Campanula, Lobe- lia (Campanulaceae), Cerastium, Dianthus, Polycarpon, Spergularia, Stellaria (Caryophyllaceae), Commelina (Commelinaceae), Fallopia (Convolvulaceae), Sempervivum (Crassulaceae), Dryopteris (Dryopte- ridaceae), Euphorbia (Euphorbiaceae), Lathyrus, Medicago, Ononis, Trigonella (Fabaceae), Geranium (Geraniaceae), Lycopus, Stachys (Lamiaceae), Malva (Malvaceae), Anacamptis, Cephalanthera, Epi- pactis, Orchis (Orchidaceae), Linaria (Plantaginaceae), Ceratochloa, Eragrostis, Festuca, Gastridium, Hyparrhenia, Molineriella, Phalaris, Phyllostachys, Setaria, Sporobolus, Stipellula (Poaceae), Anogramma (Pteridaceae), Anemonoides, Ranunculus (Ranunculaceae), Reseda (Resedaceae), Alchemilla, Kerria, Pyracantha, Rosa, Rubus (Rosa- ceae), Galium, Valantia (Rubiaceae), Thesium (Santalaceae). Infine, viene discusso lo status di conservazione delle entità e gli eventuali vincoli di protezione dei biotopi segnalati

THE VIRTUAL HISTORICAL RECONSTRUCTION OF THE CERCHIA DEI NAVIGLI OF MILAN: FROM HISTORICAL ARCHIVES, 3D SURVEY AND HBIM TO THE VIRTUAL VISUAL STORYTELLING

In the last decades, thanks to the development of eXtended Reality (XR) development platforms, research studies have envisaged new possibilities for disseminating tangible and intangible values of the past through historical virtual reconstructions. More recently, experimentation in the field of virtual archaeology has led to the development of interactive experiences based on advanced virtual and augmented reality (VR-AR) technologies. In this context, the authors intend to support the transmissibility of the historical and cultural background through validated and sustainable workflow-oriented to create virtual historical reconstruction using different sources such as 3D survey (laser scanning and digital photogrammetry), Historic Building Information Modelling (HBIM) models and historical reports. The XR project’s development included reconstructing the main historical sections and water basins of the Cerchia dei Navigli in Milan: the Conca dell’Incoronata, the Conca di Viarenna and Via Senato. The main objective is to achieve realistic and suggestive Virtual Visual Storytelling (VVS), recreating the atmospheres and scenes of everyday life when the waterways were still present. The result is engaging content on an emotional level, which leaves the visitor with dynamic memory and the feeling of reliving lost moments

BIM INTEROPERABILITY: OPEN BIM-BASED WORKFLOW FOR HERITAGE BUILDING INFORMATION MODELLING (HBIM). A MULTIDISCIPLINARY APPROACH BASED ON ADVANCED 3D TOOLS AND EXCHANGE FORMATS

In recent years we have witnessed how technology applied to built heritage has exponentially changed the daily practices of the various experts involved in the life cycle of buildings. The techniques of representation of historical architecture have been able to make use of new 3D survey tools as well as research methods capable of managing a large amount of data while improving the level of information (LOI) and accuracy of the surveyed artefacts. On the other hand, professionals still have to make use of a large number of exchange formats in order to share their digital representations (3D, 2D) and analysis. For this reason, this paper describes the research approach followed to obtain “standard” architectural representations of a heritage building in the Cultural Heritage domain. The word “standard” is used in its original meaning: “something established by authority, custom, or general consent as a model or example” (Collins Dictionary). In this context, 3D models have a primary role in the workflow because its position is in-between the 3D survey techniques that come first and the restoration/maintenance activities. The authors’ thought is that the workflow should be as smooth and sustainable as possible to have an effective standardization and collaboration among disciplines, sectors and technicians working in the different study areas